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Invitrogen™ FGR Polyclonal Antibody
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Catalog No. PIPA596050
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100 μL
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PIPA596050 100 μL
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Catalog No. PIPA596050 Supplier Invitrogen™ Supplier No. PA596050
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Description

Rabbit Polyclonal Antibody

Positive Samples: HL-60, U-937, Raji; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Lipid-anchor, Mitochondrion inner membrane, Mitochondrion intermembrane space, Peripheral membrane protein, cytoskeleton, cytosol, ruffle membrane Immunogen sequence: MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK.

FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FGR
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.92 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene FGR
Gene Accession No. P09769, P14234
Gene Alias c-fgr; c-fgr protooncogene; c-src2; c-src-2 proto-oncogene; EC 2.7.10.2; feline Gardner-Rasheed sarcoma viral oncogene; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR; FGR protein; FGR proto-oncogene, Src family tyrosine kinase; FLJ43153; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55c-fgr; p55-c-fgr protein; p55-Fgr; p58c-Fgr; p58-Fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; SRC2; Tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
Gene Symbols FGR
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGR (NP_0052391).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14191, 2268
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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