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Tocris Bioscience™ FHT 1015
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Catalog No. 76442
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Quantity:
2 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective SMARCA4/2 inhibitor

FHT 1015 is a potent and selective allosteric inhibitor of SMARCA4/SMARCA2 ATPase (also known as BRG1/BRM respectively) of the BAF (BRG/Brahma-associated factors) complex, with IC50s of ≤ 10 nM. Exhibits selectivity for SMARCA4/SMARCA2 over related CHD4 (IC50 of > 400 μM). Mutations in I1143 on SMARCA4 and I1173 on SMARCA2 render these proteins resistant to inhibition by FHT 1015. The compound induces lineage-specific changes in chromatin accessibility in different cancer cell lines, preventing binding of cancer-associated transcription factors, SOX10 and MITF transcription factors.

Specifications

Chemical Name or Material (S)-1-(Methylsulfonyl)-N-[4-(methylthio)-1-oxo-1-[[4-[3-(pyridin-4-yl)phenyl]thiazol-2-yl]amino]butan-2-yl]-1H-pyrrole-3-carboxamide
CAS 2368903-18-6
Quantity 2 mg
Target Bromodomain Inhibitors
Molecular Formula C25H25N5O4S3
Purity 0.95
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