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Tocris Bioscience™ FHT 2344
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Catalog No. 764510
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Quantity:
10 mg
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Catalog No. 76-451-0

Supplier: Tocris Bioscience™ 7645/10

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Description

Potent SMARCA2/4 inhibitor

FHT 2344 is a potent allosteric and ATP-competitive inhibitor of SMARCA2/SMARCA4 ATPases (also known as BRM/BRG1) of the BAF complex (IC50 values are 13.8 and 26.1 nM at SMARCA2 and SMARCA4, respectively). FHT 2344 inhibits SMARCA2 transcriptional activity in a BRG1-mutant cell line and SMARCA4 transcription in a BRM-mutant cell line (IC50 values are 29.8 and 30.2 nM, respectively). Dose-dependently reduces tumor growth in a uveal melanoma xenograft model and suppresses SOX10 transcription.

Specifications

Chemical Name or Material N-[(1S)-1-(Methoxymethyl)-2-[[4-[3-(1-methyl-1H-pyrazol-3-yl)phenyl]-2-thiazolyl]amino]-2-oxoethyl]-1-(methylsulfonyl)-1H-pyrrole-3-carboxamide
CAS 2468058-90-2
Quantity 10 mg
Target Bromodomain Inhibitors
Molecular Formula C23H24N6O5S2
Purity 0.95
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