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Invitrogen™ Fibrinogen Polyclonal Antibody

Catalog No. PA185429
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PA185429 1 mL
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Catalog No. PA185429 Supplier Invitrogen™ Supplier No. PA185429

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Description

Sheep Polyclonal Antibody

Sheep anti Human fibrinogen antibody recognizes human fibrinogen, a complex approximately 340 kDa hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of alpha, beta, and gamma chains linked by a series of 29 disulphide bonds (Henschen et al. 1983).

Fibrinogen, the precursor of fibrin, is the coagulable protein in the blood plasma of vertebrates. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. Fibrinogen consists as a dimer of 3 pairs of non-identical chains FGA, FGB, and FGG that are cross-linked by disulfide bonds in their N-terminal segments. The molecule has 2 terminal D domains and one central E domain, all three domains are separated when fibrinogen is degradated by plasmin. Mutations in this gene lead to several disorders, including dysfibrinogenemia, afibrinogenemia, and renal amyloidosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Fibrinogen
Applications ELISA, Immunohistochemistry (Frozen), Immunocytochemistry
Classification Polyclonal
Concentration 5 mg/mL
Conjugate Unconjugated
Formulation Glycine buffered saline with <0.1% EACA, <0.01% benzamidine, <1mM EDTA and <0.1% sodium azide; pH 7.4
Gene FGB
Gene Accession No. E9PV24, P02671, P02675, P02679, P02680, P06399, P14480, Q8K0E8, Q8VCM7
Gene Alias 2510049G14Rik; 3010002H13Rik; A-alpha fibrinogen; Ab1-181; Ab1-216; Ac1-581; Ac1873; AI256424; carboxy-terminal region; ENSMUSG00000059807; epididymis secretory sperm binding protein Li 78p; Fba5e; Fga; Fgb; Fgg; Fib; Fib2; fibg; fibrinogen; fibrinogen A-alpha chain; fibrinogen A-alpha-chain; fibrinogen alpha chain; fibrinogen alpha-E subunit; fibrinogen beta chain; Fibrinogen gamma chain; fibrinogen gamma polypeptide; fibrinogen gamma-B chain; fibrinogen gamma-chain; fibrinogen, A alpha polypeptide; fibrinogen, alpha polypeptide; fibrinogen, B beta polypeptide; fibrinogen, beta polypeptide; fibrinogen, gamma polypeptide; Fibrinopeptide A; Fibrinopeptide B; Gamma'; gamma-fibrinogen; HEL-S-78p; Liver regeneration-related protein LRRG036/LRRG043/LRRG189; MGC119422; MGC119423; MGC119425; PRO2061; testicular tissue protein Li 70; Unknown (protein for MGC:127951)
Gene Symbols FGA, FGB, FGG
Host Species Sheep
Immunogen Human fibrinogen purified from plasma.
Purification Method Ion-exchange chromatography
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110135, 14161, 2243, 2244, 2266, 24366, 24367, 361969, 99571
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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