Fibrin beta-chain Antibody (8E5), Alexa Fluor™ 488, Novus Biologicals™

Rabbit Monoclonal Antibody

Supplier:  Novus Biologicals NBP281111AF488

Catalog No. NB016329

Description

Fibrin beta-chain Monoclonal specifically detects Fibrin beta-chain in Human samples. It is validated for Flow Cytometry, ELISA.

Specifications

• Antigen: Fibrin beta-chain
• Classification: Monoclonal
• Conjugate: Alexa Fluor 488
• Formulation: 50mM Sodium Borate
• Gene Symbols: FGB
• Immunogen: 8E5 was prepared fusing Sp2/o myeloma cells with spleen cells derived from female BALB/c mice immunized with a synthetic beta-fibrin peptide seqeunce GHRPLDKC conjugated to MB-KLH (maleimidobenzoylated keyhole limpet hemocyanin).
• Quantity: 0.1 mL
• Research Discipline: Cell Cycle and Replication
• Gene ID (Entrez): 2244
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, ELISA
• Clone: 800000
• Dilution: Flow Cytometry, ELISA
• Gene Alias: Beta-Fibrinogen, epididymis secretory sperm binding protein Li 78p, fibrinogen beta chain, fibrinogen, B beta polypeptide, HEL-S-78p
• Host Species: Rabbit
• Purification Method: Protein A purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: 8E5 binds to the amino-terminal region of the beta-chain of human fibrin at an epitope consiting of GHRPLDKC. Binding is possible in both the monomeric form and the polymeric form of the protein. This peptide sequence is found only in fibrin, and not in its precursor fibrinogen and so there is no cross-reactivity with fibrinogen. Fibrin is a non-globular protein which plays a role in the clotting of blood and circulates as the precursor fibrinogen. Polymerization occurs through the action of the protease thrombin, which results in the active fibrin. Fibrin polymerizes as an insoluble matrix and forms a clot along with platelets over a wound site.
• Content And Storage: Store at 4°C in the dark.
• Isotype: IgG κ