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Fibulin 1 Mouse anti-Human, Clone: CL0337, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524598

Catalog No. PIMA524598


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Description

Description

Immunogen sequence: CESGIHNCLP DFICQNTLGS FRCRPKLQCK SGFIQDALGN CIDINECLSI SAPCPIGHTC INTEGSYTCQ KNVPNCGRGY HLNEEGTRCV DVDECAPPAE PCGKGHRCVN SPGSFRCECK TGYYFDGISR MCVDVNE Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.
Specifications

Specifications

Fibulin 1
Monoclonal
1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
P23142
Fibulin1, Fibulin 1, FIBL1, FBLN1, PP213
Mouse
IgG1
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
2192
Immunohistochemistry, Western Blot
CL0337
Unconjugated
FBLN1
Liquid
FBLN1
Recombit protein corresponding to Human Fibulin 1
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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