Invitrogen™ Fibulin 1 Monoclonal Antibody (CL0337)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524598

Catalog No. PIMA524598

Description

Immunogen sequence: CESGIHNCLP DFICQNTLGS FRCRPKLQCK SGFIQDALGN CIDINECLSI SAPCPIGHTC INTEGSYTCQ KNVPNCGRGY HLNEEGTRCV DVDECAPPAE PCGKGHRCVN SPGSFRCECK TGYYFDGISR MCVDVNE Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.

Specifications

• Antigen: Fibulin 1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P23142
• Gene Symbols: Fbln1
• Immunogen: Recombinant protein corresponding to Human Fibulin 1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: CL0337
• Conjugate: Unconjugated
• Gene: Fbln1
• Gene Alias: Basement-membrane protein 90; BM-90; BM-90/fibulin extracellular matrix glyroprotein; extracellular matrix; extracellular matrix and blood protein; FBLN; Fbln1; fbln1c; fbln1d; FIBL1; FIBL-1; fibulin 1; fibulin 1C; fibulin 1D; Fibulin1; fibulin-1; fibulin-1 C varible region; fibulin-1 D; LOW QUALITY PROTEIN: fibulin-1; PP213; wu:fc52c06
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 2192
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid