Invitrogen™ Fibulin 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA537163

Catalog No. PIPA537163

Description

This antibody detects endogenous protein at a molecular weight of 77 kDa. Purity is >95% by SDS-PAGE.

Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.

Specifications

• Antigen: Fibulin 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Fbln1
• Gene Alias: Basement-membrane protein 90; BM-90; BM-90/fibulin extracellular matrix glyroprotein; extracellular matrix; extracellular matrix and blood protein; FBLN; Fbln1; fbln1c; fbln1d; FIBL1; FIBL-1; fibulin 1; fibulin 1C; fibulin 1D; Fibulin1; fibulin-1; fibulin-1 C varible region; fibulin-1 D; LOW QUALITY PROTEIN: fibulin-1; PP213; wu:fc52c06
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14114, 2192, 315191
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P23142, Q08879
• Gene Symbols: Fbln1
• Immunogen: A synthetic peptide corresponding to residues in human Fibulin-1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov