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Invitrogen™ Fibulin 1 Polyclonal Antibody
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Catalog No. PIPA590902
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100 μL
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PIPA590902 100 μL
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Catalog No. PIPA590902 Supplier Invitrogen™ Supplier No. PA590902
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Description

Rabbit Polyclonal Antibody

Positive Samples: U-87MG, Mouse brain, Mouse heart, Mouse spleen, Rat liver, Rat kidney; Cellular Location: extracellular matrix, extracellular space Immunogen sequence: RLPCHENREC SKLPLRITYY HLSFPTNIQA PAVVFRMGPS SAVPGDSMQL AITGGNEEGF FTTRKVSPHS GVVALTKPVP EPRDLLLTVK MDLSRHGTVS S.

Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Fibulin 1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.15 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Fbln1
Gene Accession No. P23142, Q08879
Gene Alias Basement-membrane protein 90; BM-90; BM-90/fibulin extracellular matrix glyroprotein; extracellular matrix; extracellular matrix and blood protein; FBLN; Fbln1; fbln1c; fbln1d; FIBL1; FIBL-1; fibulin 1; fibulin 1C; fibulin 1D; Fibulin1; fibulin-1; fibulin-1 C varible region; fibulin-1 D; LOW QUALITY PROTEIN: fibulin-1; PP213; wu:fc52c06
Gene Symbols Fbln1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 570-670 of human FBLN1 (NP_0019872).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14114, 2192, 315191
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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