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Invitrogen™ FICD Polyclonal Antibody
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Catalog No. PIPA598950
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100 μg
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PIPA598950 100 μg
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Catalog No. PIPA598950 Supplier Invitrogen™ Supplier No. PA598950
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Description

Rabbit Polyclonal Antibody

FICD Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), ELISA

Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen FICD
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Ficd
Gene Accession No. Q6AY47, Q9BVA6
Gene Alias adenosine monophosphate-protein transferase FICD; AMPylator FICD; D5Ertd40e; De-AMPylase FICD; FIC domain containing; FIC domain protein adenylyltransferase; FIC domain-containing protein; fic S-phase protein cell division homolog; FICD; HIP13; HIP-13; huntingtin interacting protein 13; huntingtin interacting protein E; huntingtin interactor protein E; huntingtin yeast partner E; Huntingtin-interacting protein 13; huntingtin-interacting protein E; Hype; MGC5623; Protein adenylyltransferase FICD; protein adenylyltransferase FICD; adenosine monophosphate-protein transferase FICD; UNQ3041; UNQ3041/PRO9857
Gene Symbols Ficd
Host Species Rabbit
Immunogen Recombinant Human Adenosine monophosphate-protein transferase FICD protein (63-185AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11153, 288741
Target Species Human, Rat
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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