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FIH-1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501565444
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50-156-5444 10 μL
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Catalog No. 50-156-5444 Supplier Bethyl Laboratories, Inc Supplier No. A303550AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse and Zebrafish

Hydroxylates HIF-1 alpha at ′Asp-803′ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Specifications

Antigen FIH-1
Applications Immunohistochemistry, Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene HIF1AN
Gene Accession No. Q9NWT6
Gene Alias DKFZp762F1811, FIH1, FLJ20615, FLJ22027
Gene Symbols HIF1AN
Host Species Rabbit
Immunogen Between 300 and 349
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55662
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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