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FIH1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985971
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50-198-5971 100 μL
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Catalog No. 50-198-5971 Supplier Bioss Supplier No. BS4201R
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Description

Rabbit Polyclonal Antibody

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. Molecules containing the classical nuclear localization signal (NLS) are transported into the nucleus by alpha/beta heterodimers. KPNA3 has been shown to be important in the TNF-a-induced nuclear import of NF-kappa-B. It is also involved in the stress-mediated nuclear stabilization of p53 and the nuclear import and replication of HIV-1 in both dividing and non-dividing cells.

Specifications

Antigen FIH1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene HIF1AN
Gene Accession No. Q9NWT6
Gene Alias 2310046M24Rik; A830014H24Rik; DKFZp762F1811; factor inhibiting HIF1; Factor inhibiting HIF-1; FIH; FIH 1; FIH1; FIH-1; FLJ20615; FLJ22027; HIF1AN; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1, alpha subunit inhibitor; Hypoxia-inducible factor 1-alpha inhibitor; Hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
Gene Symbols HIF1AN
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human FIH1/HIF1AN.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55662
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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