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Invitrogen™ Filaggrin 2 Polyclonal Antibody

Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA555951
Description
Immunogen sequence: CGYSNSSGCG RPQNASSSCQ SHRFGGQGNQ FSYIQSGCQS GIKGGQGHGC VSGGQPSGCG QPESNPCSQS YSQRGYGARE NGQPQNCGGQ WRTGSSQSSC CG Highest antigen sequence identity to the following orthologs: Mouse - 68%, Rat - 35%.
The FLG2 protein is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. FLG2 is also required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.
Specifications
Filaggrin 2 | |
Polyclonal | |
Unconjugated | |
FLG2 | |
filaggrin family member 2; filaggrin-2; FLG2; FLG-2; Ifapsoriasin; IFPS; intermediate filament-associated and psoriasis susceptibility protein; intermediate filament-associated and psoriasis-susceptibility protein | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
388698 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.08 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q5D862 | |
FLG2 | |
Recombinant protein corresponding to Human Filaggrin 2. Recombinant protein control fragment (Product #RP-94294). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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