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Filaggrin Antibody (FLG/1563), Alexa Fluor™ 488, Novus Biologicals™
SDP

Catalog No. NB009096 Shop All R&D Systems Products
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NB009096 0.1 mL
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Catalog No. NB009096 Supplier Novus Biologicals Supplier No. NBP275774AF488
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Description

Mouse Monoclonal Antibody

Filaggrin Monoclonal specifically detects Filaggrin in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Specifications

Antigen Filaggrin
Applications Immunohistochemistry, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone FLG/1563
Conjugate Alexa Fluor 488
Dilution Immunohistochemistry, Immunohistochemistry-Paraffin
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias ATOD2, epidermal filaggrin, filaggrin, Profilaggrin
Gene Symbols FLG
Host Species Mouse
Immunogen Recombinant human Filaggrin protein fragment (around aa 998-1104) (exact sequence is proprietary) (Uniprot: P20930)
Purification Method Protein A or G purified
Quantity 0.1 mL
Regulatory Status RUO
Research Discipline Cell Biology, Cellular Markers
Primary or Secondary Primary
Test Specificity Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Target Species Human
Content And Storage Store at 4°C in the dark.
Isotype IgG2b κ
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