Filaggrin, Mouse anti-Human, DyLight 594, Clone: FLG/1563, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Novus Biologicals NBP275774DL594
DescriptionFilaggrin Monoclonal antibody specifically detects Filaggrin in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry (Paraffin).
|50mM Sodium Borate with 0.05% Sodium Azide|
|Recombinant human Filaggrin protein fragment (around aa 998-1104) (exact sequence is proprietary)|
|Protein A or G purified|
|Store at 4°C in the dark.|
|Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.|
|ATOD2, epidermal filaggrin, filaggrin, Profilaggrin|
|Cell Biology, Cellular Markers|
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