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Tocris Bioscience™ FK 866
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Catalog No. 807210
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10 mg
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80-721-0 10 mg
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Catalog No. 80-721-0 Supplier Tocris Bioscience™ Supplier No. 8072/10
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Description

Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy

FK 866 is a non-competitive and high-affinity inhibitor of NAMPT (nicotinamide phosphoribosyltransferase, PBEF1) (Ki = 0.3 nM); inhibits NAD biosynthesis. Induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 ~1 nM). Induces apoptosis in four different neuroblastoma cell lines; also induces autophagy in SH-SY5Y cells. Potentiates the cytotoxic effects induced by Etoposide (Cat. No. 1226) and Cisplatin (Cat. No. 2251).

Specifications

Chemical Name or Material (2E)-N-[4-(1-Benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2-propenamide
CAS 658084-64-1
Quantity 10 mg
Target NAMPT Inhibitors
Molecular Formula C24H29N3O2
Purity 98%
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