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Invitrogen™ FK506 Monoclonal Antibody (FK1)
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Catalog No. PIMA190186
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100 μg
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Catalog No. Quantity
PIMA190186 100 μg
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Catalog No. PIMA190186 Supplier Invitrogen™ Supplier No. MA190186
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Description

Mouse Monoclonal Antibody

This antibody recognizes conjugated and non-conjugated FK-506 with apparent dissociation constant Kd=10^9M.

Tacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [National Center for Biotechnology Information. PubChem Compound Database; CID=445643].
TRUSTED_SUSTAINABILITY

Specifications

Antigen FK506
Applications ELISA
Classification Monoclonal
Clone FK1
Concentration 6 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.09% sodium azide; pH 8.0
Gene Alias C44H69NO12; FK-506; Fujimycin; Tacrolimus
Host Species Mouse
Immunogen Conjugate FK-506-BSA.
Purification Method Euglobulin precipitation, Size-exclusion - Dialysis
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgM
Target Molecule Chemical
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