Invitrogen™ FKBP15 Polyclonal Antibody

Catalog No.	Quantity
PIPA5144010	100 μg

Catalog No. PIPA5144010 Supplier Invitrogen™ Supplier No. PA5144010

Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human Hacat whole cell, human Raji whole cell, mouse lung tissue. IHC: human spleen tissue, human tonsil tissue, mouse brain tissue, rat brain tissue, human breast tissue, human lymphoma tissue. ICC/IF: MCF-7 cell. Flow: JK cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

Specifications

• Antigen: FKBP15
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: FKBP15
• Gene Accession No.: Q5T1M5, Q6P9Q6
• Gene Alias: 133 kDa FK506-binding protein; 133 kDa FKBP; BB131447; C430014M02Rik; FK506 binding protein 15; FK506 binding protein 15, 133kDa; FK506-binding protein 133; FK506-binding protein 133kDa; FK506-binding protein 15; FKBO133; Fkbp133; FKBP-133; FKBP15; FKBP-15; Kiaa0674; mKIAA0674; PPP1R76; protein phosphatase 1, regulatory subunit 76; RGD1304816; WAFL; WASP and FKBP-like; WASP- and FKBP-like protein; WASP and FKBP-like protein
• Gene Symbols: FKBP15
• Host Species: Rabbit
• Immunogen: E.coli-derived human FKBP135/FKBP15 recombinant protein (Position: A19-D1210).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23307, 338355, 362528
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG