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FKBP1A Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 102731AP150UL

Encompass_Preferred

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Catalog No. 50-172-6169


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Description

Description

Immunophilins are a family of soluble receptors capable of binding to one of two major immunosuppressant agents; cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Immunophilins function as cis-trans peptidyl-prolyl isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. Thus, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline-containing proteins. FKBP12:FK506 complexes inhibit calcineurin, a calcium/calmodulin-dependent serine/threonine phosphatase which blocks T-cell activation by preventing lymphokine gene transcription. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.
Specifications

Specifications

FKBP1A
Polyclonal
Unconjugated
FKBP1A
12 kDa FK506 binding protein, 12 kDa FKBP, FK506 binding protein 1A, FKBP 12, FKBP 1A, FKBP1, FKBP12, FKBP12C, FKBP1A, Immunophilin FKBP12, PKC12, PKCI2, PPIASE, PPIase FKBP1A, Rotamase
Rabbit
Antigen Affinity Chromatography
RUO
14225, 2280
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.26 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P26883, P62942
FKBP1A
FKBP1A Fusion Protein Ag0406
150 μL
Primary
Human, Mouse
Antibody
IgG
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