Invitrogen™ FKBP25 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA593277

Catalog No. PIPA593277

Description

Immunogen sequence: MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID; Positive Samples: HeLa, MCF-7, BT-474; Cellular Location: Nucleus.

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

Specifications

• Antigen: FKBP25
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FKBP3
• Gene Alias: 25 kDa FK506-binding protein; 25 kDa FKBP; 25kDa; FK506 binding protein 3; FK506 binding protein 3, 25kDa; FK506-binding protein 25, T-cell; FK506-binding protein 3; FK506-binding protein 3 (25kD); FKBP25; FKBP-25; Fkbp3; FKBP-3; Immunophilin FKBP25; peptidyl-prolyl cis-trans isomerase FKBP3; PPIase; PPIase FKBP3; rapamycin binding protein; rapamycin-selective 25 kDa immunophilin; Rotamase
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2287
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot
• Concentration: 0.54 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q00688
• Gene Symbols: FKBP3
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human FKBP3 (NP_0020041).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov