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Invitrogen™ FLI1 Polyclonal Antibody
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Catalog No. PIPA595146
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100 μg
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PIPA595146 100 μg
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Catalog No. PIPA595146 Supplier Invitrogen™ Supplier No. PA595146
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: JURKAT Cell, RAJI Cell. IHC: Human Tonsil Tissue, Rat Spleen Tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The FLI1 (Friend Leukemia Integration 1) gene is located on chromosome 11q24.3 and belongs to the ETS (E26 transformation-specific) family of transcription factors. Structurally, FLI1 contains an ETS domain responsible for DNA binding and a pointed domain which facilitates protein-protein interactions. Functionally, it plays a critical role in the regulation of embryonic and hematopoietic development. It is also implicated in the pathogenesis of diseases such as Ewing's sarcoma, wherein a chromosomal translocation t(11;22)(q24;q12) forms the EWS-FLI1 fusion gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FLI1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 5mg BSA and 0.05mg thimerosal, 0.05mg sodium azide
Gene Fli1
Gene Accession No. P26323, Q01543
Gene Alias Ewing sarcoma breakpoint region 2; EWSR2; Fli1; Fli-1; Fli-1 proto-oncogene, ETS transcription factor; Friend leukemia integration 1; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; Retroviral integration site protein Fli-1; Sic1; SIC-1; transcription factor ERGB
Gene Symbols Fli1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence at the N-terminus of human FLI1 (54-73aa QQEWINQPVRVNVKREYDHM).
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14247, 2313, 315532
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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