Invitrogen™ FLRG Polyclonal Antibody

Catalog No.	Quantity
PIPA587771	100 μL

Catalog No. PIPA587771 Supplier Invitrogen™ Supplier No. PA587771

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGSGNPAPGG VCWLQQGQEA TCSLVLQTDV TRAECCASGN IDTAWSNLTH PGNKINLLGF LGLVHCLPCK DSCDGVECGP GKACRMLGGR PRCECAPDCS GLPARLQVCG SDGATYRDEC ELRAARCRGH PDLSVMYRGR CRKSCEHVVC PRPQSCVVDQ TGSAHCVVCR AAPCPVPSSP GQELCGNNNV TYISSCHMRQ ATCFLGRSIG VRHAGSCAGT PEEPPGGESA EEEENFV; Positive Samples: HeLa, DU145, MCF-7, SKOV3, Mouse lung, Mouse kidney, Rat lung; Cellular Location: Nucleus.

Follistatin-like 3 (FSTL3) is a gene located on chromosome 19p13.3 and encodes a secreted glycoprotein that belongs to the follistatin-related protein family. FSTL3 functions as an antagonist to members of the transforming growth factor-beta (TGF-β) superfamily, particularly inhibiting activin and myostatin signaling. This inhibitory action is crucial for regulating muscle growth, fertility, and inflammation. FSTL3 is expressed in various tissues, including the placenta, gonads, and skeletal muscle, where it modulates physiological processes by binding to and neutralizing the activities of its target ligands. Dysregulation of FSTL3 has been implicated in conditions such as muscle wasting, metabolic syndrome, and reproductive disorders, reflecting its role in maintaining tissue homeostasis and function. Research into FSTL3 focuses on its potential therapeutic applications in diseases involving TGF-β pathway dysregulation, offering insights into strategies for modulating growth factor activities in clinical settings.

Specifications

• Antigen: FLRG
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 2.36 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: FSTL3
• Gene Accession No.: O95633, Q99PW7, Q9EQC7
• Gene Alias: E030038F23Rik; FLRG; FLRGFSRP; follistatin like 3; follistatin-like 3; follistatin-like 3 (secreted glycoprotein); follistatin-like protein 3; Follistatin-related gene protein; follistatin-related protein 3; FSRP; FSTL3; UNQ674/PRO1308
• Gene Symbols: FSTL3
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_0058511).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10272, 114031, 83554
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG