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Invitrogen™ FLT3 Monoclonal Antibody (BV10A4), PE

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA110090

Catalog No. PIMA110090


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Description

Description

This antibody reacts with an extracellular epitope of CD135 (FLT3, FLK2, STK-1), a 130-160 kDa type I transmembrane receptor tyrosine kinase that is involved in early steps of hematopoiesis. This antibody will not cross-react with mouse.

FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

FLT3
Monoclonal
PE
FLT3
B230315G04; CD135; CD135 antigen; fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK2; Flk-2; FLT3; Flt-3; fms related tyrosine kinase 3; FMS-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; Ly72; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; stem cell tyrosine kinase 1; STK1; STK-1; tyrosine-protein kinase FLT3; tyrosine-protein kinase receptor flk-2; wmfl
Mouse
Size-exclusion chromatography
RUO
2322
4°C, store in dark, DO NOT FREEZE!
Liquid
Flow Cytometry
BV10A4
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
P36888
FLT3
BV-173 leukemic cell line.
100 Tests
Primary
Human
Antibody
IgG1
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