FLT4 Monoclonal Antibody (OTI9G6), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA806910

Catalog No. 50-168-1313

Description

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

Specifications

• Antigen: FLT4
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P35916
• Gene Symbols: FLT4
• Immunogen: Human recombit protein fragment corresponding to amino acids 1063-1363 of human FLT4 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI9G6
• Conjugate: Unconjugated
• Gene: FLT4
• Gene Alias: FLT-4, FLT41, LMPH1A, PCL, VEGFR-3, VEGFR3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2324
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid