FLT4 Mouse anti-Human, Clone: OTI9G6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF806910

Catalog No. 50-166-8035

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.

Specifications

• Antigen: FLT4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: FLT4
• Gene Alias: FLT-4, FLT41, LMPH1A, PCL, VEGFR-3, VEGFR3
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2324
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI9G6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: P35916
• Gene Symbols: FLT4
• Immunogen: Human recombit protein fragment corresponding to amino acids 1063-1363 of human FLT4 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1