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Invitrogen™ FLT4 Polyclonal Antibody
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Catalog No. PIPA5109730
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100 μL
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PIPA5109730 100 μL
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Catalog No. PIPA5109730 Supplier Invitrogen™ Supplier No. PA5109730
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: YYNWVSFPGC LARGAETRGS SRMKTFEEFP MTPTTYKGSV DNQTDSGMVL ASEEFEQIES RHRQESGFSC KGPGQNVAVT RAHPDSQGRR RRPERGARGG.

Vascular endothelial growth factor is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues. Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specificl ymphatic endothelial receptor VEGFR-3. In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos. Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5. Thus, VEGFR3 has an essential role in the development of theembryonic cardiovascular system before the emergence of the lymphatic vessels.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FLT4
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene FLT4
Gene Accession No. P35916
Gene Alias AI323512; Chy; chylous ascites; Flt4; FLT-4; FLT41; fms related tyrosine kinase 4; FMS-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; PCL; receptor protein tyrosine kinase; soluble VEGFR 3; sVEGFR 3; tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; vascular endothelial growth factor receptor-3; VEGF R3; VEGFR3; VEGFR-3
Gene Symbols FLT4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1230-1329 of human VEGFR3/FLT4 (NP_8915552).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2324
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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