Fluconazole, 99%

Description

Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase. | CAS: 86386-73-4 | C13H12F2N6O | 306.277 g/mol

Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants

Specifications

Chemical Identifiers

• CAS: 86386-73-4
• Molecular Formula: C13H12F2N6O
• Molecular Weight (g/mol): 306.277
• MDL Number: MFCD00274549
• InChI Key: RFHAOTPXVQNOHP-UHFFFAOYSA-N
• Synonym: fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
• PubChem CID: 3365
• ChEBI: CHEBI:46081
• IUPAC Name: 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
• SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

• Melting Point: 138°C to 140°C
• Color: White
• Density: 1.05
• Quantity: 25 g
• Merck Index: 14,4122
• Solubility Information: Soluble indimethylsulfoxide and ethanol.
• Formula Weight: 306.27
• Percent Purity: 99%
• Physical Form: Crystalline Powder
• Chemical Name or Material: Fluconazole

Safety and Handling

Hazard Category	H302-H315-H319-H360D
Hazard Statement	GHS H Statement H302-H315-H319-H335 Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P201-P202-P264b-P270-P280i-P281-P301+P312-P302+P352-P305+P351+P338-P308+P313-P330-P332+P313-P362-P501c
RTECSNumber	XZ4810000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only