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  5. Tocris Bioscience™ FM19G11

Tocris Bioscience™ FM19G11
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Catalog No. 66535
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66-535 5 mg
66-532-5 25 mg
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Catalog No. 66-535 Supplier Tocris Bioscience™ Supplier No. 6653/5
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Description

HIF α-subunit inhibitor

FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

Specifications

Chemical Name or Material 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
CAS 329932-55-0
Quantity 5 mg
Molecular Formula C23H17N3O8
Formula Weight 463.4
Purity 98%
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