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Tocris Bioscience™ FMF-04-159-2
GREENER_CHOICE

Catalog No. 715810
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent covalent CDK14 and CDK16 inhibitor; also inhibits other TAIRE kinase family members

FMF-04-159-2 is a potent inhibitor of CDK14 and CDK16 (IC50 = 40 nM for CDK14 in cellular BRET assay; IC50 values are 88 and 10 nM for CDK14 and CDK16 in kinase activity inhibition assay, respectively). Inhibits other TAIRE kinase family members at 1 μM (CDK17 and CDK18). Also binds CDK2 (IC50 = 256 nM). Displays covalent binding of CDK14, with binding sustained after washout. Causes cell cycle arrest at G2/M in cancer cell lines. Reversible control FMF-04-159-R (Cat. No. 7159) also available.

Specifications

Chemical Name or Material N-[1-[[3-[[(2 E)-4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]phenyl]sulfonyl]-4-piperidinyl]-4-[(2,4,6- trichlorobenzoyl)amino]-1 H-pyrazole-3-carboxamide
CAS 2364489-81-4
Quantity 10 mg
Target Cyclin-dependent Kinase Inhibitors
Molecular Formula C28H30Cl3N7O5S
Purity 0.98
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