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Tocris Bioscience™ Fmk
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Catalog No. 469010
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Irreversible ribosomal S6 kinase 1/2 inhibitor

Fmk is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.

Specifications

Chemical Name or Material 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
CAS 821794-92-7
Quantity 10 mg
Molecular Formula C18H19FN4O2
Formula Weight 342.37
Purity 97%
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