Invitrogen™ FMO5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552932

Catalog No. PIPA552932

Description

Immunogen sequence: PLGAIMPISE LQGRWATQVF KGLKTLPSQS EMMAEISKAQ EEIDKRYVES QRHTIQGDYI DTMEELADLV GVRPNLLSLA FTDPKLALHL LLGPCTPIHY RVQGPGKWDG ARKAILTTDD Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: FMO5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FMO5
• Gene Alias: 5033418D19Rik; AI195026; Dimethylaniline monooxygenase [N-oxide-forming] 5; dimethylaniline oxidase 5; flavin containing monooxygenase 5; FMO 5; Fmo5; Hepatic flavin-containing monooxygenase 5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2330
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P49326
• Gene Symbols: FMO5
• Immunogen: Recombinant protein corresponding to Human FMO5. Recombinant protein control fragment (Product #RP-90221).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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