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Invitrogen™ FN3KRP Polyclonal Antibody
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Catalog No. PIPA564249
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100 μL
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PIPA564249 100 μL
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Catalog No. PIPA564249 Supplier Invitrogen™ Supplier No. PA564249
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GSVLVMEHMD MRHLSSHAAK LGAQLADLHL DNKKLGEMRL KEAGTVGRGG GQEERPFVAR FGFDVVTCCG YLPQVNDWQE DWVVFYARQR IQPQMD Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 83%.

Fructosamine-3-kinase related protein (FN3KRP) is located on chromosome 17q25.3, approximately 8 kb upstream of the FN3K gene. It shares 65% amino acid identity with FN3K and possesses an identical genomic organization, implying functional similarities; FN3KRP is suggested to play a role in enzymatic deglycation. Unlike FN3K, FN3KRP is more ancient, present in diverse organisms such as cyanobacteria, echinoderms, plants, and cold-blooded vertebrates. Studies have discovered a significant association between rs1046896 in FN3KRP and longevity, where the longevity allele C is linked to increased FN3KRP expression in whole blood. FN3KRP is hypothesized to phosphorylate glucitolamines, products of non-enzymatic glycation, indicating its involvement in crucial metabolic processes. The regulation of both FN3K and FN3KRP is notable for TATA-less and CAAT-less promoters, featuring homologous CpG islands and Sp1 binding sites. Meanwhile, both genes are widely expressed across human tissues, but FN3K demonstrates significantly higher levels in tissues prone to glycation-related complications.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FN3KRP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene FN3KRP
Gene Accession No. Q9HA64
Gene Alias FN3KL; FN3K-related protein; Fn3krp; FN3K-RP; fructosamine 3 kinase related protein; fructosamine 3-kinase-related protein; fructosamine-3-kinase-related protein; Ketosamine-3-kinase; ortholog of human fructosamine-3-kinase-related protein FN3KRP; Protein-psicosamine 3-kinase FN3KRP; RGD1304570; testis secretory sperm-binding protein Li 211a
Gene Symbols FN3KRP
Host Species Rabbit
Immunogen Recombinant protein fragment of Human FN3KRP (Product #RP-103613)
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79672
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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