Invitrogen™ FN3KRP Polyclonal Antibody

Catalog No.	Quantity
PIPA566002	100 μL

Catalog No. PIPA566002 Supplier Invitrogen™ Supplier No. PA566002

Description

Rabbit Polyclonal Antibody

Immunogen sequence: GSVLVMEHMDM RHLSSHAAKL GAQLADLHLD NKKLGEMRLK EAGTVGRGGG QEERPFVARF GFDVVTCCGY LPQVNDWQED WVVFYARQRI QPQMD Highest antigen sequence identity to the following orthologs - mouse 80%, rat 83%.

Fructosamine-3-kinase related protein (FN3KRP) is located on chromosome 17q25.3, approximately 8 kb upstream of the FN3K gene. It shares 65% amino acid identity with FN3K and possesses an identical genomic organization, implying functional similarities; FN3KRP is suggested to play a role in enzymatic deglycation. Unlike FN3K, FN3KRP is more ancient, present in diverse organisms such as cyanobacteria, echinoderms, plants, and cold-blooded vertebrates. Studies have discovered a significant association between rs1046896 in FN3KRP and longevity, where the longevity allele C is linked to increased FN3KRP expression in whole blood. FN3KRP is hypothesized to phosphorylate glucitolamines, products of non-enzymatic glycation, indicating its involvement in crucial metabolic processes. The regulation of both FN3K and FN3KRP is notable for TATA-less and CAAT-less promoters, featuring homologous CpG islands and Sp1 binding sites. Meanwhile, both genes are widely expressed across human tissues, but FN3K demonstrates significantly higher levels in tissues prone to glycation-related complications.

Specifications

• Antigen: FN3KRP
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: FN3KRP
• Gene Accession No.: Q9HA64
• Gene Alias: FN3KL; FN3K-related protein; Fn3krp; FN3K-RP; fructosamine 3 kinase related protein; fructosamine 3-kinase-related protein; fructosamine-3-kinase-related protein; Ketosamine-3-kinase; ortholog of human fructosamine-3-kinase-related protein FN3KRP; Protein-psicosamine 3-kinase FN3KRP; RGD1304570; testis secretory sperm-binding protein Li 211a
• Gene Symbols: FN3KRP
• Host Species: Rabbit
• Immunogen: Recombinant Human FN3KRP. Recombinant protein control fragment (Product #RP-103613).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 79672
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG