Invitrogen™ FNTB Recombinant Rabbit Monoclonal Antibody (5H4)

Catalog No.	Quantity
PIMA538339	100 μL

Catalog No. PIMA538339

Supplier: Invitrogen™ MA538339

Description

Rabbit Recombinant Monoclonal Antibody

This antibody has been tested in direct-ELISA.

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.

Specifications

• Antigen: FNTB
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 5H4
• Concentration: 1.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 150 mM NaCl and 0.02% sodium azide; pH 7.4
• Gene: FNTB
• Gene Accession No.: P49356, Q02293
• Gene Alias: 2010013E13Rik; AA409500; CAAX farnesyltransferase subunit beta; EC 2.5.1.58; farnesyl-protein transferase beta-subunit; farnesyltransferase beta subunit; farnesyltransferase, CAAX box, beta; FNTB; FPTB; ft beta; FTase beta; FTase-beta; LOW QUALITY PROTEIN: protein farnesyltransferase subunit beta; protein farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta
• Gene Symbols: FNTB
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human FNTB.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2342, 64511
• Target Species: Human, Rat
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG