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Invitrogen™ FNTB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106707

Catalog No. PIPA5106707


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Description

Description

Antibody detects endogenous levels of total FNTB.

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

FNTB
Polyclonal
Unconjugated
FNTB
2010013E13Rik; AA409500; CAAX farnesyltransferase subunit beta; EC 2.5.1.58; farnesyl-protein transferase beta-subunit; farnesyltransferase beta subunit; farnesyltransferase, CAAX box, beta; FNTB; FPTB; ft beta; FTase beta; FTase-beta; LOW QUALITY PROTEIN: protein farnesyltransferase subunit beta; protein farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta
Rabbit
Affinity Chromatography
RUO
110606, 2342, 64511
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P49356, Q02293, Q8K2I1
FNTB
A synthesized peptide derived from human FNTB(Accession P49356), corresponding to amino acid residues C254-Q304.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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