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Invitrogen™ FNTB Polyclonal Antibody
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Catalog No. PIPA530036
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100 μL
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PIPA530036 100 μL
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Catalog No. PIPA530036 Supplier Invitrogen™ Supplier No. PA530036
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (97%), Rat (98%), Pig (97%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (97%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FNTB
Applications Western Blot
Classification Polyclonal
Concentration 0.29 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene FNTB
Gene Accession No. P49356
Gene Alias 2010013E13Rik; AA409500; CAAX farnesyltransferase subunit beta; EC 2.5.1.58; farnesyl-protein transferase beta-subunit; farnesyltransferase beta subunit; farnesyltransferase, CAAX box, beta; FNTB; FPTB; ft beta; FTase beta; FTase-beta; LOW QUALITY PROTEIN: protein farnesyltransferase subunit beta; protein farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta
Gene Symbols FNTB
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human FNTB. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2342
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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