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FNTB Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501570347
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50-157-0347 10 μL
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Catalog No. 50-157-0347 Supplier Bethyl Laboratories, Inc Supplier No. A305407AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.

Specifications

Antigen FNTB
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene FNTB
Gene Accession No. P49356
Gene Alias Protein farnesyltransferase subunit beta; FTase-beta; EC 2.5.1.58; CAAX farnesyltransferase subunit beta; RAS proteins prenyltransferase beta; FNTB
Gene Symbols FNTB
Host Species Rabbit
Immunogen Between 387 and 437
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2342
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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