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Invitrogen™ FNTB Recombinant Rabbit Monoclonal Antibody (3I4X5)
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Catalog No. PIMA538049
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PIMA538049 100 μL
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Catalog No. PIMA538049 Supplier Invitrogen™ Supplier No. MA538049
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Samples: HeLa, 293T, A-431, Rat brain Immunogen sequence: MASPSSFTYY CPPSSSPVWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEKIQEVFS SYKFNHLVPR LVLQREKHFH YLKRGLRQLT DAYECLDASR.

Eukaryotic cells contain 3 different types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in a variety of proteins. These posttranslational modifications provide a mechanism for membrane localization of proteins that lack a transmembrane domain. CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This enzyme has the ability to farnesylate peptides as short as 4 residues in length that conform to the CAAX consensus sequence. The gene for the beta subunit of CAAX farnesyltransferase (FNTB) has been pinpointed to 14q23-q24 by Southern blot hybridization and PCR analyses of panels of human/Chinese hamster somatic cell hybrid lines and by fluorescence chromosomal in situ hybridization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FNTB
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone 3I4X5
Concentration 1.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene FNTB
Gene Accession No. P49356, Q02293
Gene Alias 2010013E13Rik; AA409500; CAAX farnesyltransferase subunit beta; EC 2.5.1.58; farnesyl-protein transferase beta-subunit; farnesyltransferase beta subunit; farnesyltransferase, CAAX box, beta; FNTB; FPTB; ft beta; FTase beta; FTase-beta; LOW QUALITY PROTEIN: protein farnesyltransferase subunit beta; protein farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta
Gene Symbols FNTB
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FNTB (P49356).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2342, 64511
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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