Invitrogen™ Folic acid Monoclonal Antibody (2B7)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549697

Catalog No. PIMA549697

Description

Antibody tested in indirect ELISA.

Folic acid, a B-vitamin essential for numerous biochemical processes, plays a key role in DNA synthesis and repair, as well as methylation, which is crucial for genome regulation and normal mammalian development. It functions primarily as a methyl-group donor and is involved in critical biological processes such as cell division and gene expression regulation. This vitamin is integral to folate metabolism, which has significant implications for DNA methylation and thereby impacts epigenetic modifications. Variations in dietary intake and functional polymorphisms in the genes encoding folate metabolism enzymes can influence its efficacy, making it a potential factor in cancer susceptibility and other diseases. Folic acid deficiency is common and can arise from poor diet, malabsorption, alcohol use, obesity, and kidney failure. Due to its protective effects against neural tube defects and ischemic events, folic acid fortification in foods has been adopted in many countries. The molecular interaction of folic acid with DNA and RNA occurs at different sites, highlighting its multifaceted role in cellular processes. Overall, folic acid's impact on DNA methylation underscores its importance in health and disease prevention.

Specifications

• Antigen: Folic acid
• Classification: Monoclonal
• Concentration: 5.3 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Immunogen: Conjugate of FA hapten and KLH.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry, Lateral Flow
• Clone: 2B7
• Conjugate: Unconjugated
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG