Invitrogen™ FOLR3 Monoclonal Antibody (OTI6C1)

Catalog No.	Quantity
PIMA527489	100 μL

Catalog No. PIMA527489 Supplier Invitrogen™ Supplier No. MA527489

Description

Mouse Monoclonal Antibody

FOLR3 Monoclonal Antibody for IHC (P)

Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, alpha, beta, gamma, gamma' (which is produced by alternative splicing) and delta. beta-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. gamma-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of delta-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The alpha isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.

Specifications

• Antigen: FOLR3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI6C1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: FOLR3
• Gene Accession No.: P41439
• Gene Alias: Folate receptor 3; folate receptor 3 (gamma); folate receptor gamma; FOLR3; FR gamma; FR- gamma; FR-G; FR-gamma; gamma-hFR
• Gene Symbols: FOLR3
• Host Species: Mouse
• Immunogen: Full length human recombinant protein of FOLR3 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2352
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1