FOLR3 Mouse anti-Human, Clone: OTI6C1, lyophilized, TrueMAB™

Catalog No.	Quantity
50-167-0717	100 μg

Catalog No. 50-167-0717 Supplier OriGene Supplier No. CF811551

Description

Mouse Monoclonal Antibody

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, alpha, beta, gamma, gamma′ (which is produced by alternative splicing) and delta. beta-FR is attached to the membrane by a GPI anchor and is expressed in maligt tissues of epithelial and nonepithelial origin. gamma-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of delta-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The alpha isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.

Specifications

• Antigen: FOLR3
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI6C1
• Conjugate: Unconjugated
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene: FOLR3
• Gene Accession No.: P41439
• Gene Alias: FR-G, FR-gamma, gamma-hFR
• Gene Symbols: FOLR3
• Host Species: Mouse
• Immunogen: Full length human recombit protein of human FOLR3 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2352
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG1