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Invitrogen™ FOLR3 Polyclonal Antibody
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Catalog No. PIPA547718
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100 μg
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PIPA547718 100 μg
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Catalog No. PIPA547718 Supplier Invitrogen™ Supplier No. PA547718
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Description

Sheep Polyclonal Antibody

In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) FOLR2 is observed and less than 1% cross-reactivity with rhFOLR1 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, alpha, beta, gamma, gamma' (which is produced by alternative splicing) and delta. beta-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. gamma-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of delta-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The alpha isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FOLR3
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene FOLR3
Gene Accession No. P41439
Gene Alias Folate receptor 3; folate receptor 3 (gamma); folate receptor gamma; FOLR3; FR gamma; FR- gamma; FR-G; FR-gamma; gamma-hFR
Gene Symbols FOLR3
Host Species Sheep
Immunogen Mouse myeloma cell line NS0-derived recombinant human FOLR3 long isoform Ala20-Ser243.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2352
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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