Invitrogen™ FOLR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103844

Catalog No. PIPA5103844

Description

Antibody detects endogenous levels of total FOLR3.

Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydrofolate into the cell. The folate receptors consist of five members, alpha, beta, gamma, gamma' (which is produced by alternative splicing) and delta. beta-FR is attached to the membrane by a GPI anchor and is expressed in malignant tissues of epithelial and nonepithelial origin. gamma-FR is expressed in tissues of hematopoietic origin, such as spleen, thymus and bone marrow. The expression pattern of delta-FR is elusive, which suggests that it is highly restricted both spatially and temporally. The alpha isoform of the folate receptor is used as a highly selective tumor marker and may be targeted for the delivery of therapeutic compounds to tumor cells by coupling to derivatives of folic acid.

Specifications

• Antigen: FOLR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FOLR3
• Gene Alias: Folate receptor 3; folate receptor 3 (gamma); folate receptor gamma; FOLR3; FR gamma; FR- gamma; FR-G; FR-gamma; gamma-hFR
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2352
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P41439
• Gene Symbols: FOLR3
• Immunogen: A synthesized peptide derived from human FOLR3(Accession P41439), corresponding to amino acid residues R206-S243.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov