Invitrogen™ FOXL2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585078

Catalog No. PIPA585078

Description

Keep as concentrated solution. Predicted reactivity: Mouse (100%), Pig (100%), Rabbit (100%), Bovine (100%). Positive Control: mouse eye. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical role evolutionarily, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and in further follicle development and/or maintenance. Immunohistochemical data shows that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo any major posttranslational modifications. FOXL2 is also found to be associated with blepharo-phimosis/ptosis/epicanthus inverses syndrome (BPES). There are two forms of BPES. Type I BPES shows eyelid abnormal-ities that are associated with ovarian failure. In type II BPES, only eyelid defects are found. Studies have shown that FOXL2 is expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.

Specifications

• Antigen: FOXL2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: FOXL2
• Gene Alias: AU045128; Blepharophimosis; BPES; BPES1; epicanthus inversus; forkhead box L2; forkhead box protein L2; forkhead transcription factor; forkhead transcription factor FOXL2; forkhead transcription factor L2; Foxl2; LUSTR2; MGC14393; Pfrk; P-Frk; PINTO; pituitary forkhead factor; POF3; putative transcription factor foxl2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26927, 668
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O88470, P58012
• Gene Symbols: FOXL2
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FOXL2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG