FOXP1 Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-157-2606	10 μL
50-157-2605	100 μL

Catalog No. 50-157-2606 Supplier Bethyl Laboratories, Inc Supplier No. IHC00724T

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Rat, X. laevis, X. tropicalis, Bovine, Dog, Horse, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpa

Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintaice of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). {ECO:0000250; UniProtKB:P58462, ECO:0000269; PubMed:15286807, ECO:0000269; PubMed:18640093, ECO:0000269; PubMed:18799727, ECO:0000269; PubMed:24023716, ECO:0000269; PubMed:25267198, ECO:0000269; PubMed:26647308, ECO:0000305; PubMed:18347093, ECO:0000305; PubMed:24023716}.; Isoform 8: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5′-CGATACAA-3′ (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency. {ECO:0000250; UniProtKB:P58462, ECO:0000269; PubMed:21924763}.

Specifications

• Antigen: FOXP1
• Applications: Immunohistochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: FOXP1
• Gene Accession No.: P58462, Q9H334
• Gene Alias: 12CC4, FLJ23741, HSPC215, MGC12942, MGC88572, MGC99551, QRF1, hFKH1B
• Gene Symbols: Foxp1
• Host Species: Rabbit
• Immunogen: Between 627 and 677
• Purification Method: Antigen affinity chromatography
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 108655, 27086
• Target Species: Human, Mouse
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG