Invitrogen™ FOXP2 Monoclonal Antibody (CL5312)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531419

Catalog No. PIMA531419

Description

Immunogen sequence: AQQLVFQQQL LQMQQLQQQQ HLLSLQRQGL ISIPPGQAAL PVQSLPQAGL SPAEIQQLWK EVTGVHSMED NGIKHGGLDL TTNNSSSTTS SNTSKASPPI THHS.

FOXP2 is a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.

Specifications

• Antigen: FOXP2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O15409, P0CF24, P58463
• Gene Symbols: FOXP2
• Immunogen: Recombinant protein corresponding to Human FOXP2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Clone: CL5312
• Conjugate: Unconjugated
• Gene: FOXP2
• Gene Alias: 2810043D05Rik; AI449000; CAG repeat protein 44; CAG-16; CAGH44; D0Kist7; DKFZp686H1726; forkhead box P2; forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; OTTHUMP00000196932; RGD1559697; SPCH1; TNRC10; trinucleotide repeat containing 10; trinucleotide repeat-containing gene 10 protein
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 114142, 500037, 93986
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov