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Invitrogen™ FOXP3 Monoclonal Antibody (22510), HRP
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Catalog No. PIMA514683
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PIMA514683 100 μL
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Catalog No. PIMA514683 Supplier Invitrogen™ Supplier No. MA514683
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Description

Mouse Monoclonal Antibody

MA5-14683 targets FOXP3 in IHC (P) and WB applications and shows reactivity with Human samples. The MA5-14683 immunogen is synthetic peptide derived from within residues 400 to the C-terminus of Human FOXP3. MA5-14683 detects FOXP3 which has a predicted molecular weight of approximately 50 kDa. Store antibody at 4°C for 1-2 weeks. For long-term storage, store at -20°C.

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FOXP3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 22510
Concentration 0.5 mg/mL
Conjugate HRP
Formulation PBS with 1% BSA, 30% glycerol and 0.1% ProClin 300; pH 7.4
Gene Foxp3
Gene Accession No. Q9BZS1
Gene Alias AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Gene Symbols Foxp3
Host Species Mouse
Immunogen Synthetic peptide derived from within residues 400 to the C-terminus of Human FOXP3.
Purification Method IgG fraction
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50943
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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