FoxP3 Mouse anti-Human, PE, Clone: 259D/C7, BD

Mouse Monoclonal Antibody

Supplier:  BD Biosciences 560046

Catalog No. BDB560046

Description

The 259D/C7 antibody reacts with the human FoxP3 transcription factor, a member of the forkhead or winged helix family of transcription factors. The expression of FoxP3, also known as Scurfin, IPEX and JM2, has been found to be associated with CD4+ regulatory T cells and represents a specific marker for these cells. Flow-cytometric analysis has shown that FoxP3 is expressed by the majority of CD4+CD25+high T cells in peripheral blood while less than half of CD4+CD25int cell population are FoxP3 positive. Approximately 5-10% of peripheral CD4+ cells are CD4+CD25+ T regulatory cells. T regulatory cells are thought to play a critical role in the control of T cell mediated autoimmunity by suppressing the proliferation and cytokine production of other T cells. To support this hypothesis, it has been found that FOXP3 is mutated in scurfy (sf) mice. The 259D/C7 antibody reacts with all currently identified isoforms of human FoxP3 and is cross-reactive with Cynomolgus, Rhesus and Baboon. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.

Host Species: Mouse
Clone: 259D/C7
IsoType: IgG1
Cross Reactivity: Human

Flow Cytometry

Specifications

• Antigen: FoxP3
• Classification: Monoclonal
• Conjugate: PE
• Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
• Immunogen: FoxP3 recombinant protein
• Quantity: 100 Tests
• Research Discipline: Immunology
• Target Species: Baboon, Cynomolgus, Human, Rhesus Monkey
• Isotype: IgG1

• Applications: Flow Cytometry
• Clone: 259D/C7
• Description: Scurfin, IPEX, JM2
• Host Species: Mouse
• Purification Method: Affinity Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov

For Research Use Only.