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FoxP3 Mouse, Clone: SPM579, Novus Biologicals™
SDP

Catalog No. NBP234385B Shop All R&D Systems Products
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Catalog No. Quantity
NBP234385B 0.2 mg
NBP234385F 0.02 mg
NBP234385A 0.1 mg
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Catalog No. NBP234385B Supplier Novus Biologicals Supplier No. NBP2343850.2MG

Description

Mouse Monoclonal Antibody

FoxP3 Monoclonal antibody specifically detects Antigen in Human, Mouse, Primate samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation.

Specifications

Antigen FoxP3
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone SPM579
Conjugate Unconjugated
Dilution Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug, Immunohistochemistry-Paraffin 0.5-ug/ml
Formulation PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Accession No. Q9BZS1
Gene Alias AIID, AIIDMGC141961, DIETER, forkhead box P3, Forkhead Box Protein P3, FOXP3delta7, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, Immunodeficiency, Polyendocrinopathy, Enteropathy, X-Linked, IPEX, JM2, MGC141961, MGC141963, PIDX, PIDXMGC141963, Scurfin, XPID, XPIDpolyendocrinopathy, enteropathy, X-linked
Gene Symbols FOXP3
Host Species Mouse
Immunogen Full-length human FOXP3 protein
Molecular Weight of Antigen 51 kDa
Purification Method Protein A purified
Quantity 0.2 mg
Regulatory Status RUO
Research Discipline Adaptive Immunity, Cell Biology, Chromatin Research, Immunology, Transcription Factors and Regulators
Primary or Secondary Primary
Gene ID (Entrez) 50943
Test Specificity Recognizes a protein of 47-55kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
Target Species Human, Mouse, Primate
Content And Storage Store at 4C.
Form Purified
Isotype IgG1 κ
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