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FOXP3 Monoclonal Antibody (FJK-16s), eFluor™ 570, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

Supplier:  Invitrogen 41577382

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Catalog No. 50-112-3632


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Description

Description

Description: The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells. Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human. Applications Reported: This FJK-16s antibody has been reported for use in immunohistochemical staining of frozen tissue sections and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This FJK-16s antibody has been tested by immunohistochemistry of frozen mouse spleen at less than or equal to 5 μg/mL.

FOXP3 Monoclonal antibody specifically detects FOXP3 in Bovine, Canine, Feline, Mouse, Porcine, Rat samples. It is validated for Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin).
TRUSTED_SUSTAINABILITY
Specifications

Specifications

FOXP3
Monoclonal
0.2 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q99JB6
Foxp3
Affinity chromatography
RUO
100037405, 20371, 317382, 444998, 491876, 506053
4° C, store in dark, DO NOT FREEZE!
Liquid
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
FJK-16s
eFluor 570
Foxp3
AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Rat
100 μg
Primary
Bovine, Canine, Feline, Mouse, Porcine, Rat
Antibody
IgG2a κ
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