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  6. Invitrogen™ FOXP3 Recombinant Rabbit Monoclonal Antibody (BLR034F)

Invitrogen™ FOXP3 Recombinant Rabbit Monoclonal Antibody (BLR034F)
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Catalog No. PIMA544263
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100 μL
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PIMA544263 100 μL
PIMA544264 10 μL
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Catalog No. PIMA544263 Supplier Invitrogen™ Supplier No. MA544263
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen FOXP3
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR034F
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 8.2
Gene Foxp3
Gene Accession No. Q9BZS1
Gene Alias AIID; DIETER; forkhead box P3; forkhead box protein P3; Forkhead box protein P3 41 kDa form; Forkhead box protein P3, C-terminally processed; forkhead/winged helix transcription factor 3; Foxp3; FOXP3delta7; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; IPEX; JM2; MGC141961; MGC141963; PIDX; regulatory protein Foxp3; RGD1562112; RP23-54C14.1; scurfin; scurfy; sf; XPID
Gene Symbols Foxp3
Host Species Rabbit
Immunogen Peptide representing a region between residue 275 and 325 of human Forkhead box P3.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50943
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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